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LEUKOCYTE COMMON ANTIGENS
Descriptors Found:
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DeCS
Descriptor
English
:
Antigens, CD45
Descriptor
Spanish
:
Antígenos CD45
Descriptor
Portuguese
:
Antígenos CD45
Synonyms
English
:
CD45 Antigens
CD45R Antigens
CD45RA Antigens
CD45RO Antigens
Leukocyte Common Antigens
Protein Tyrosine Phosphatase, Receptor Type, C
Tree Number:
D08.811.277.352.650.775.400.100.500
D12.644.360.587.100.500
D12.776.476.592.100.500
D12.776.543.733.937.500
D23.050.301.264.035.145
D23.101.100.110.145
Definition
English
:
High-molecular weight
glycoproteins
uniquely expressed on the surface of
LEUKOCYTES
and their hemopoietic progenitors. They contain a cytoplasmic protein
tyrosine
phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45
antigens
occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
History Note
English
:
93; was CD45 ANTIGEN (NM) 1984-92; RT7 ANTIGEN was RT7 (SY) to HISTOCOMPATIBILITY ANTIGENS RT (NM); B220 ANTIGEN was NM 1990-95
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
30830
Unique Identifier:
D017493
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS